Complete list of publications Pubmed

Loughman JA, Caparon MG. 2006. A novel adaptation of aldolase regulates virulence in Streptococcus pyogenes. EMBO J. In Press.

Loughman JA, Caparon MG. 2006. Regulation of SpeB in Streptococcus pyogenes by pH and NaCl: A model for in vivo gene expression. J Bacteriol. 188(2):399-408. Abstract

Meehl MA, Pinkner JS, Anderson PJ, Hultgren SJ, Caparon MG. 2005. A novel endogenous inhibitor of secreted streptococcal NAD-glycohydrolase. PLoSl. 1(4):0362-0372. Abstract

Rosch J, Caparon MG. 2005. The ExPortal: An organelle dedicated to the biogenesis of secreted proteins in Streptococcus pyogenes. Mol. Microbiol. 58(4):959-968. Abstract

Cho KH, Caparon MG. 2005. Patterns of virulence gene expression differ between biofilm and tisssue communities of Streptococcus pyogenes. Mol. Microbiol. 57(6):1545-56. Abstract

Kau AL, Martin SM, Lyon W, Hayes E, Caparon MG, Hultgren SJ. 2005. Enterococcus faecalis tropism for the kidneys in the urinary tract of C57BL/6J mice. Infect Immun. 73(4):2461-8. Abstract

Brenot A, King KY, Caparon MG. 2005.The PerR regulon in peroxide resistance and virulence of Streptococcus pyogenes. Mol. Microbiol. 55(1):221-34. Abstract

Rosch J, Caparon MG. 2004. A microdomain for protein secretion in gram-positive bacteria. Science.304(5676):1513-5 PubMed Abstract / Free Abstract / Free Full Text

Meehl MA, Caparon MG. 2004. Specificity of streptolysin O in cytolysin-mediated translocation. Mol. Microbiol. 52(6):1665-76 Abstract

Nyberg P, Sakai T, Cho KH, Caparon MG, Fassler , Bjorck L. 2004. Interactions with fibronectin attenuate the virulence of Streptococcus pyogenes. EMBO J. 23(10): 2166-74. Abstract

Lyon WR, Caparon MG. 2004. Role for serine protease HtrA (DegP) of Streptococcus pyogenes in the biogenesis of virulence factors SpeB and the hemolysin streptolysin S.
Infect Immun. 72(3):1618-25 Abstract

Brenot A, King KY, Janowiak B, Griffith O, Caparon MG. 2004. Contribution of glutathione peroxidase to the virulence of Streptococcus pyogenes. Infect Immun. 72(1):408-13 Abstract

Neely MN, Lyon WR, Runft DL, Caparon M. 2003. Role of RopB in growth phase expression of the SpeB cysteine protease of Streptococcus pyogenes. J Bacteriol. 185(17):5166-74 Abstract

Lyon WR, Caparon MG. 2003. Trigger factor-mediated prolyl isomerization influences maturation of the Streptococcus pyogenes cysteine protease. J Bacteriol. 185(12):3661-7. Abstract

Neely MN, Pfeifer JD, Caparon M. 2002. Streptococcus-zebrafish model of bacterial pathogenesis. Infect Immun. 70(7):3904-14. Abstract

Gibson CM, Caparon MG. 2002. Alkaline phosphatase reporter transposon for identification of genes encoding secreted proteins in gram-positive microorganisms. Appl Environ Microbiol. 68(2):928-32. Abstract

Lyon WR, Madden JC, Levin JC, Stein JL, Caparon MG. 2001. Mutation of luxS affects growth and virulence factor expression in Streptococcus pyogenes. Mol Microbiol. 42(1):145-57. Abstract

Francis KP, Yu J, Bellinger-Kawahara C, Joh D, Hawkinson MJ, Xiao G, Purchio TF, Caparon MG, Lipsitch M, Contag PR. 2001. Visualizing pneumococcal infections in the lungs of live mice using bioluminescent Streptococcus pneumoniae transformed with a novel gram-positive lux transposon. Infect Immun. 69(5):3350-8. Abstract

Madden JC, Ruiz N, Caparon M. 2001. Cytolysin-mediated translocation (CMT): a functional equivalent of type III secretion in gram-positive bacteria. Cell. 104(1):143-52. Abstract

King KY, Horenstein JA, Caparon MG. 2000. Aerotolerance and peroxide resistance in peroxidase and PerR mutants of Streptococcus pyogenes. J Bacteriol. 182(19):5290-9. Abstract

Granok A, Parsonage D, Ross RP, Caparon MG. 1999. The RofA binding site of Streptococcus pyogenes is utilized by multiple transcriptional pathways. J. Bacteriol. 182:1529-1540 Abstract

Gibson CM, Mallett TC, Claiborne A, Caparon MG. 1999. Contribution of NADH oxidase to the aerobic metabolism of Streptococcus pyogenes. J. Bacteriol. 182: 448-455 Abstract

Okada N, Tatsuno I, Hanski E, Caparon M, Sasakawa C. 1998. Streptococcus pyogenes protein F promotes invasion of HeLa cells. Microbiology. 144 ( Pt 11):3079-86. Abstract

Lyon W, Gibson C, Caparon M. 1998. A role for Trigger Factor and an Rgg-like regulator in the transcription, secretion and processing of the cysteine proteinase of Streptococcus pyogenes. EMBO J. 21:6263-6275 Abstract

Ruiz N, Wang B, Pentland A, Caparon M. 1997. Streptolysin O and adherence synergistically modulate proinflammatory responses of keratinocytes to group A streptococci. Mol. Microbiol. 27:337-346 Abstract

Okada N, Watarai M, Ozeri V, Hanski E, Caparon M, Sasakawa C. 1997. A Matrix form of fibronectin mediates enhanced binding of Streptocococcus pyogenes to host tissue. J. Biol. Chem. 272:26987-26984 Abstract

Fogg GC, Caparon MG. 1997. Constitutive expression of fibronectin-binding in Streptococcus pyogenes as a result of anaerobic activation of rofA. J. Bacteriol. 179:6172-6180 Abstract

Wang B, Ruiz N, Pentland A, Caparon M. 1997. Keratinocyte proinflammatory responses to adherent and non-adherent group A streptococci. Infect. Immun. 65:2119-2126 Abstract

Gibson CM, Caparon MG. 1996. Insertional inactivation of Streptococcus pyogenes sod suggests prtF is regulated in response to a superoxide signal. J. Bacteriol. 178:4688-4695 Abstract

Jaffe J, Natanson-Yaron S, Caparon MG, Hanski E. 1996. Protein F2, a novel fibronectin binding protein from Streptococcus pyogenes posses two binding domains. Mol. Microbiol. 21:373-384 Abstract

Ozeri V, Tovi A, Burstein I, Natanson-Yaron S, Caparon MG, Yamada KM, Akiyama SK, Vlodavsky I, Hanski E. 1996. A two-domain mechanism for group A streptococcal adherence through protein F to the extracellular matrix. EMBO 15:989-98 Abstract

Lee, Ju-Y, Caparon M. 1996. An oxygen-induced but protein F-independent fibronectin binding pathway in Streptococcus pyogenes. Infect. Immun. 64:413-421 Abstract

Kihlberg BM, Cooney J, Caparon MG, Olsen A, Bjorck L. 1995. Biological properties of a Streptococcus pyogenes mutant generated by Tn916 insertion in mga. Microbial Pathogenesis19:299-315 Abstract

Natanson S, Sela S, Moses A, Musser JM, Caparon MG, Hanski E. 1995. Distribution of fibronectin-binding proteins among group A streptococci of different M types. J. Infect. Dis. 171:871-878.30 Abstract

Okada N, Liszewski K, Atkinson JP, Caparon M. 1995. Membrane co-factor protein (MCP or CD46) is a keratinocyte receptor for the M protein of the group A streptococcus. Proc. Natl. Acad. Sci. USA. 92:2489-2493 Abstract

Perez-Casal J, Okada N, Caparon M, Scott JR. 1995. Role of the conserved C repeat region of the M protein of Streptococcus pyogenes. Mol. Microbiol. 15:907-916 Abstract

Okada N, Pentland AP, Falk P, Caparon MG. 1994. M protein and protein F act as important determinants of cell-specific tropism of Streptococcus pyogenes in skin tissue. J. Clin. Invest. 94:965-977 Abstract

Fogg G, Gibson C, Caparon MG. 1994. The identification of rofA , a positive-acting regulatory component of prtF expression: Use of a mgd-based shuttle mutagenesis strategy in Streptococcus pyogenes. Mol. Microbiol. 11:671-684 Abstract

Sela S, Aviv A, Tovi A, Burstein I, Caparon MG, Hanski E. 1994. Protein F: an adhesin of Streptococcus pyogenes binds fibronectin via two distinct domains at two different binding sites. Mol. Microbiol. 10:1049-1055 Abstract

Geist RT, Okada N, Caparon MG. 1993. Analysis of Streptococcus pyogenes promoters using Novel Tn916 -based shuttle vectors for the construction of transcriptional fusions to CAT. J. Bacteriol. 175:7561-7570 Abstract

VanHeyningen T, Fogg G, Yates D, Hanski E, Caparon MG. 1993. Adherence and fibronectin-binding are environmentally regulated in group A streptococci. Mol. Microbiol. 9:1213-1221 Abstract

Okada N, Geist RT, Caparon MG. 1993. Positive transcriptional control of mry regulates virulence in the group A streptococcus. Mol. Microbiol. 7:893-903 Abstract

Hanski E, Horwitz P, Caparon MG. 1992. Expression of protein F, the fibronectin-binding protein of Streptococcus pyogenes JRS4, in heterologous streptococcal and enterococcal strains promotes their adherence to respiratory epithelial cells. Infect. Immun. 60:5119-5125 Abstract

Perez-Casal J, Caparon MG, Scott JR. 1992. Introduction of the emm 6 gene into an emm-deletion strain of Streptococcus pyogenes restores its ability to resist phagocytosis. Res. in Microbiol. 143:549-558 Abstract

Caparon MG, Geist RT, Perez-Casal J, Scott JR. 1992. Environmental regulation of virulence in group A streptococci: Transcription of the gene encoding the M protein is stimulated by carbon dioxide. J. Bacteriol. 174:5693-5701 Abstract

Hanski E, Caparon MG. 1992. Protein F, a fibronectin-binding protein, is an adhesin of the group A streptococcus. Proc. Natl. Acad. Sci. USA. 89:6172-6176 Abstract

Perez-Casal J, Caparon MG, Scott JR. 1991. Mry, a trans-acting positive regulator of the M protein gene of Streptococcus pyogenes with similarity to the receptor proteins of two-component regulatory systems. J. Bacteriol. 173:2617-2624 Abstract

Caparon MG, Stevens DS, Olsen A, Scott JR. 1991. Role of M protein in adherence of group A streptococci. Infect. Immun. 59:1811-1817 Abstract

Caparon MG, Scott JR. 1989. Excision and Insertion of the conjugative transposon Tn916 involves a novel recombination mechanism. Cell. 59: 1027-1034 Abstract

Norgren M, Caparon MG, Scott JR. 1989. A method for allelic replacement using the conjugative transposon Tn916: deletion of the emm 6.1 allele in Streptococcus pyogenes. Infect. Immun. 57: 3856-3862 Abstract

Scott JR, Kirchman PA, Caparon MG. 1988. An intermediate in transposition of the conjugative transposon Tn 916. Proc. Natl. Acad. USA Sci 85: 4809-4813 Abstract

Caparon MG, Johnson W. 1988. Macrophage toxicity and complement sensitivity of virulent and avirulent strains of Legionella pneumophila. Rev. Infect. Dis. 10:S377-S381 Abstract

Caparon MG, Scott JR. 1987. Identification of a gene that regulates expression of M protein, the major virulence determinant of group A streptococci. Proc. Natl. Acad. Sci. USA 84:8677-8681 Abstract